GLP-1 medications – a class of drugs originally developed to treat diabetes and now used for weight management and longevity – help regulate appetite, gastric emptying, and post-meal glucose. When comparing popular GLP-1 medications, you may notice that they differ in mechanism, dosing schedule, delivery route, and tolerability. Understanding these differences prepares you for a productive conversation with your plastic surgeon about risks, benefits, and monitoring.
The Short List of Popular GLP-1 Medications
Most comparisons include these popular GLP-1 medications:
- Semaglutide: GLP-1 agonist that is available as a weekly injection or an oral form
- Tirzepatide: Dual GIP/GLP-1 agonist available as a weekly injection with a broader incretin target
Each GLP-1 medication has specific approvals, contraindications, and titration protocols. For longevity, often a microdosing schedule may be used.
How GLP-1 Medications Work
All GLP-1 agonists stimulate the GLP-1 receptor, which supports glucose-dependent insulin secretion and reduces appetite signals. Some agents also slow your gastric emptying, which can influence fullness cues. Tirzepatide is called a dual incretin because it acts on both GIP and GLP-1 receptors. The dual incretin is a mechanistic distinction rather than a guarantee of superior outcomes for every person. However, many users find that it is more effective for visceral (internal) fat.
In practice, clinicians compare the mechanisms of the common GLP-1 drugs and choose one that matches your medical history, preferences, and response over time.
Dosing and Delivery
Daily injections (e.g., liraglutide) suit people who prefer smaller, more frequent doses and steady routines. Weekly injections (e.g., semaglutide, tirzepatide, dulaglutide, and exenatide ER) offer convenience but still require careful titration and consistent day-of-week use.
When comparing your options, the choice of a GLP-1 drug often relies on your ability to administer the medication consistently, your comfort with injections, and drug cost. You can discuss these topics with our clinician to determine which medication is right for you.
Tolerability and Safety
Common side effects of popular GLP-1 medications are usually transient and can include:
- Nausea
- Diarrhea
- Constipation
- Early satiety
- Gastrointestinal upset during dose escalation
Hydration, changes to meal size, and slower titration may help with these effects.
Prescribers screen for contraindications (e.g., certain endocrine tumor syndromes) and review your medical history for past issues, such as pancreatitis, when evaluating whether GLP-1 medication is appropriate. Since risks and monitoring needs vary by individual and by GLP-1 drug, you should rely on your clinician for personalized guidance and instructions.
Call Us Today To Learn More About Common GLP-1 Drugs
If you need support building a broader health span strategy, PHASE Plastic Surgery & Longevity can help you understand the differences when comparing popular GLP-1 medications. Call us today for a consultation.
